Ligands for E3 Ligase

Ligase

E3 ligase-recruiting Moiety

Ligands for E3 Ligase

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Related Products (347)
Antibodies (2)
Related Compound Screening Libraries (1)
Ligands for E3 Ligase Isoform Comparison

By Effects:	Controls (2) Ligands (3) Inhibitors (3) Degraders (2) Modulators (3) Chemicals (2)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-A0003

Lenalidomide	191732-72-6	99.95%
Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

HY-10984

Pomalidomide	19171-19-8	99.96%
Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors.

HY-101488

CC-885	1010100-07-8	99.85%
CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 is also a known degrader of GSPT1, inhibiting protein translation.

HY-14658

Thalidomide	50-35-1	99.98%
Thalidomide inhibits cereblon (CRBN), a part of the cullin-4 E3 ubiquitin ligase complex CUL4-RBX1-DDB1, with a K_d of ∼250 nM, and has immunomodulatory, anti-inflammatory and anti-angiogenic cancer properties. Thalidomide can work as molecular glue to potentiate substrate.

HY-130800

Eragidomide	1860875-51-9	99.86%
Eragidomide (CC-90009) is a first-in-class GSPT1-selective cereblon (CRBN) E3 ligase modulator, acts as a molecular glue. Eragidomide coopts the CRL4^CRBN to selectively target GSPT1 for ubiquitination and proteasomal degradation.

HY-W460193

N-Me-Thalidomide 4-fluoride	2244520-92-9	99.41%
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, used for the synthesis of Anti-inflammatory agent 70 (HY-157570).

HY-W440247

CRBN ligand-109	2758533-77-4	≥98.0%
CRBN ligand-109 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

HY-W244657

3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione	191732-74-8
3-(6-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of the CRBN protein.

HY-101291

Iberdomide	1323403-33-3	99.54%
Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC₅₀ of ~150 nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities.

HY-160695

PT-179	2924858-25-1	99.91%
PT-179 is an orthogonal Thalidomide (HY-14658) derivative that targets cereblon without causing off-target degradation effects. PT-179 is able to specifically bind CRBN, form a ternary complex with a target protein fused to a zinc finger (ZF) degron, and mediate the degradation of the tagged protein. For example, PT-179 binds to the ubiquitin ligase substrate receptor cereblon by forming a complex with SD40 and efficiently degrades proteins N- or C-terminally fused to SD40 or SD36 (DC50 for eGFP: 4.5 nM and 14.3 nM). PT-179 can be used to develop compact protein degradation tagging platforms.

HY-100947

VH-298	2097381-85-4	99.78%
VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a K_d value of 80 to 90 nM. VH-298 leads to HIF-α accumulation inside HeLa cells. VH-298 is an E3 ligase Ligand, and can be used for synthesis of PROTACs.

HY-120217

VH032	1448188-62-2	99.64%
VH032 is a VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. VH032 is a VHL/HIF-1α interaction inhibitor with a K_dPROTACs.

HY-42424

(S,R,S)-AHPC-Me hydrochloride	1948273-03-7	99.59%
(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me hydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-125845

(S,R,S)-AHPC	1448297-52-6	99.13%
(S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC₅₀ of 1.11 μM in Ba/F3 cells.

HY-101763A

(S,R,S)-AHPC monohydrochloride	1448189-80-7	99.83%
(S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

HY-146237

Golcadomide	2379572-34-4
Golcadomide (CC-99282) is a potent and orally active CRBN E3 ligase modulator (CELMoD). Golcadomide interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, inducing the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide shows potential for research in cancer-related fields, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL).

HY-W382038

E3 ligase Ligand 32	2300099-98-1	99.95%
E3 ligase Ligand 32 (First product in Example 52) is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 32 can be connected to the ligand for protein by a linker to form PROTACs and can be used for the synthesis of PROTAC SMARCA2/4-degrader-29 (HY-162743).

HY-A0003B

Lenalidomide hemihydrate	847871-99-2	99.98%
Lenalidomide hemihydrate (CC-5013 hemihydrate), a derivative of Thalidomide, acts as molecular glue. Lenalidomide hemihydrate is an orally active immunomodulator. Lenalidomide hemihydrate (CC-5013 hemihydrate) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide hemihydrate (CC-5013 hemihydrate) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

HY-112078

(S,R,S)-AHPC-Me	1948273-02-6	99.48%
(S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC₅₀ <1 nM.

HY-41547

Thalidomide 4-fluoride	835616-60-9	99.92%
Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966).

E3 Ligase Ligand Library

Compound library containing several ligands for E3 ligase.

74compounds HY-L128

Lenalidomide			Cereblon								99.95%
Pomalidomide			Cereblon								99.96%
CC-885			Cereblon Cereblon								99.85%
Eragidomide			Cereblon								99.86%
N-Me-Thalidomide 4-fluoride			Cereblon Cereblon								99.41%
CRBN ligand-109			Cereblon								≥98.0%
Iberdomide			Cereblon Cereblon								99.54%
PT-179			Cereblon Cereblon								99.91%
VH-298	VHL										99.78%
VH032	VHL										99.64%
(S,R,S)-AHPC-Me hydrochloride	VHL										99.59%
(S,R,S)-AHPC	VHL										99.13%
(S,R,S)-AHPC monohydrochloride	VHL										99.83%
Golcadomide			Cereblon
E3 ligase Ligand 32	VHL										99.95%
Lenalidomide hemihydrate			Cereblon								99.98%
(S,R,S)-AHPC-Me	VHL										99.48%
ALV2			Cereblon Cereblon								98.07%
Lenalidomide-Br			Cereblon								99.86%
BC-1215						Fbxo3					99.93%
ALV1			Cereblon								98.62%
VH032-cyclopropane-F	VHL										99.92%
ZXH-1-161			Cereblon Cereblon								98.43%
(S,S,S)-AHPC hydrochloride	VHL										99.42%
(S)-Thalidomide			Cereblon								99.52%
Lenalidomide-OH			Cereblon								99.48%
NV03										UHRF1	98.82%
VH 101, acid	VHL										98.37%
Lenalidomide-I			Cereblon Cereblon								99.90%
Biotin-Thalidomide			Cereblon								99.65%
(S,R,S)-AHPC-propargyl	VHL										99.46%
cIAP1 ligand 1				cIAP1							99.90%
Nutlin carboxylic acid		MDM2									98.63%
VHL-IN-1	VHL										99.78%
DCAF1 binder 1			Cereblon Cereblon								99.12%
VHL Ligand 8	VHL										98.04%
CCW16							RNF4				98.73%
CC-3060			Cereblon Cereblon								99.7%
VL285	VHL										98.84%
BMS-986397			Cereblon Cereblon								99.76%
KB02-COOH			Cereblon								99.39%
PD 4'-oxyacetic acid			Cereblon Cereblon								99.69%
TD-106			Cereblon Cereblon								99.81%
(S,R,S)-AHPC-Me dihydrochloride	VHL										99.84%
(S,R,S)-AHPC-Boc	VHL
VHL Ligand 14	VHL										99.93%
AR antagonist 1 hydrochloride	VHL										99.53%
CRBN modulator-1			Cereblon								98.00%
2-Methoxyphenyl dihydrouracil			Cereblon
CC-17369			Cereblon								98.68%
(R,S,S)-VH032	VHL
Pomalidomide-5-OH			Cereblon								99.46%
E3 ligase Ligand 23			Cereblon								99.71%
Lenalidomide-F			Cereblon								99.89%
OICR-8268			Cereblon Cereblon
Thalidomide (Standard)			Cereblon Cereblon
Lenalidomide 5'-piperazine			Cereblon Cereblon								99.92%
CRBN ligand-9			Cereblon Cereblon								≥98.0%
Thalidomide-piperazine hydrochloride			Cereblon								98.27%
Pomalidomide-d₃			Cereblon Cereblon								≥99.0%
VL285 Phenol	VHL										98.56%
VH 101, thiol	VHL										98.66%
Lenalidomide (Standard)			Cereblon Cereblon
E3 ligase Ligand 18			Cereblon								99.22%
Lenalidomide 5'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
Thalidomide-pyrrolidine hydrochloride			Cereblon Cereblon								≥98.0%
Cereblon inhibitor 1			Cereblon								99.19%
Thalidomide-d₄			Cereblon								98.00%
Lenalidomide-d₅			Cereblon Cereblon								99.32%
E3 ligase Ligand 8				IAP IAP							99.32%
Cereblon inhibitor 2			Cereblon Cereblon								98.86%
VH032 thiol	VHL
Pomalidomide-6-OH			Cereblon								98.09%
Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride			Cereblon Cereblon								98.08%
CRBN ligand-13			Cereblon
(R)-Thalidomide			Cereblon								99.80%
Lenalidomide hydrochloride			Cereblon
Pomalidomide-d₄			Cereblon Cereblon
(S,R,S)-AHPC TFA	VHL
Aster-A Ligand-3			Cereblon
E3 ligase Ligand 26			Cereblon
E3 ligase Ligand 42			Cereblon
E3 ligase Ligand 22			Cereblon
Pomalidomide-5-O-CH3			Cereblon
E3 ligase Ligand 10				IAP IAP
DA-PROTAC	VHL
(4R,5S)-Nutlin carboxylic acid		MDM2
PROTAC CRBN ligand-2			Cereblon
Thalidomide-(2)piperidine			Cereblon Cereblon
HOXB7 8–25		MDM2
E3 ligase Ligand 14				IAP IAP
E3 ligase Ligand 48			Cereblon
E3 ligase Ligand 38			Cereblon
CRBN ligand-17			Cereblon
Lenalidomide-¹³C₅,¹⁵N			Cereblon Cereblon
E3 ligase Ligand 57			Cereblon
(S,R,R)-VH032	VHL
E3 ligase Ligand 37	VHL
E3 ligase Ligand 36	VHL
E3 ligase Ligand PG			Cereblon, IC₅₀: 2.191 μM
(S,R,S)-AHPC-Ala	VHL
Pomalidomide-piperazine			Cereblon Cereblon
Bestatin-amido-Me				cIAP1
E3 ligase Ligand 31			Cereblon
Cyclopropane-(S,R,S)-AHPC	VHL
E3 ligase Ligand 44	VHL
cis VH-298	VHL
E3 ligase Ligand 27	VHL
VH032 analogue-2	VHL
E3 ligase Ligand 25			Cereblon
(S)-Deoxy-thalidomide-Br			Cereblon
Acepromazine-OTs			Cereblon
E3 ligase Ligand 21			Cereblon
VH032-CH2-Boc	VHL
(S)-Deoxy-thalidomide			Cereblon Cereblon
MV-1-NH-Me				cIAP1
E3 ligase Ligand 13				IAP IAP
(R)-Pomalidomide-pyrrolidine			Cereblon Cereblon
(S,R,S,R)-AHPC-Me	VHL
CRBN ligand-11			Cereblon
Thalidomide-azetidine-CHO			Cereblon Cereblon
MY-11B									DCAF1
Ru-Poma			Cereblon Cereblon
E3 ligase Ligand 45	VHL
VH032 analogue-1	VHL
BCL-xL/BCL-2 ligand 1	VHL
HL389			Cereblon
(3S)Lenalidomide-5-Br			Cereblon
VH032-NH-CO-CH2-NHBoc	VHL
GNE7599	VHL
tDHU, acid			Cereblon Cereblon								98.83%
Pomalidomide 5'-fluoro-6'-piperazine-4-methylpiperidine hydrochloride			Cereblon Cereblon
E3 ligase Ligand 34	VHL
Me-SJ46411	VHL
MEL23		MDM2
OICR-8268-acrylic acid	VHL
RR-11055			Cereblon Cereblon
N-Boc-SBP-0636457-OH				cIAP1
E3 ubiquitin ligase binder-1			Cereblon Cereblon
Thalidomide-methylpyrrolidine			Cereblon Cereblon
SJF-0661	VHL
(S,R,S)-AHPC-Ac	VHL
Pomalidomide-d₅			Cereblon Cereblon
E3 ligase Ligand 33	VHL
(S,R,S)-AHPC-O-CF3	VHL
(S,R,S)-AHPC dihydrochloride	VHL
E3 ligase Ligand 35	VHL
SJ46411-Br	VHL
E3 ligase Ligand 43	VHL
E3 ligase Ligand 7								DCAF11
E3 ligase Ligand 41			Cereblon
AS1411-C4-VH032		MDM2
VHL-SF2	VHL
cIAP1 ligand 2				cIAP1
L321			Cereblon
CRBN ligand-1			Cereblon Cereblon
Pomalidomide-¹⁵N,¹³C₅			Cereblon Cereblon
cIAP1 ligand 4				IAP IAP
Pomalidomide-6-O-CH3			Cereblon
E3 ligase Ligand 29	VHL
SOS1 Ligand intermediate-2	VHL
CRBN ligand-181			Cereblon
CRBN ligand-111			Cereblon
CRBN ligand-76			Cereblon
CRBN ligand-148			Cereblon
CRBN ligand-14			Cereblon
AR antagonist 1	VHL
CRBN ligand-183			Cereblon
CRBN ligand-110			Cereblon
CRBN ligand-63			Cereblon
3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon
CRBN ligand-164			Cereblon
CRBN ligand-162			Cereblon
BWA-522 intermediate-1			Cereblon Cereblon								99.27%
3-(4-Bromo-2-chlorophenyl)piperidine-2,6-dione			Cereblon
Pomalidomide (Standard)			Cereblon Cereblon
Phenyl-glutarimide 4'-oxyacetic acid			Cereblon Cereblon
CRBN ligand-45			Cereblon
SJ6145					KLHDC2
CRBN ligand-112			Cereblon
CRBN ligand-74			Cereblon
CRBN ligand-16			Cereblon
CRBN ligand-84			Cereblon
E3 ligase Ligand 30	VHL
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph	VHL
CRBN ligand-47			Cereblon
(S,R,S)-AHPC(Me)-amido-C2-acid	VHL
CRBN ligand-83			Cereblon
3-(4-Bromo-2-fluorophenyl)piperidine-2,6-dione			Cereblon
SOS1 Ligand intermediate-1	VHL
CRBN ligand-108			Cereblon
Thalidomide-5-piperazine			Cereblon Cereblon

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Ligands for E3 Ligase

Ligands for E3 Ligase

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Isoform Specific Products:

Ligands for E3 Ligase Related Products (347)

Antibodies (2)

Related Compound Screening Libraries (1)

Ligands for E3 Ligase Isoform Comparison

Ligands for E3 Ligase Related Products (347):